Safavi, M., Foroumadi, A., Nakhjiri, M., Abdollahi, M., Shafiee, A., Ilkhani, H., Ganjali,M., Hosseinimehr, S.J., Emami, S.
Bioorg Med Chem Lett. 2010; 20 (10): 3070-3073. (ISI, 2.42 )

A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics. The SOD-like activity of parent ligands and complexes were determined by the inhibition of nitroblue tetrazolium (NBT) reduction method, using xanthine/xanthine oxidase as the superoxide radical generator. The obtained results indicate that Cu(II) complexes exhibited the most potent SOD-like activities with the IC50 values ranging from ca. 0.2 to 4 μM. Among copper complexes, 2-hydroxy-4-methoxyacetophenone semicarbazone analog was the most active compounds (IC50 ≈0.2 μM).

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