Department: 
Catalysis & Inorganic Chemical Technology
Project manager(s): 
Year: 
2020
Berberine as a natural alkaloid with chemical formula C20H18NO4+ and yellow color exists in different parts of plants, such as leaves, stems, barks and roots and can be extracted. This compound has many applications in traditional and modern medicine. For example, berberine has been effective in reducing cholesterol and obesity and treating diabetes and has proven its antioxidant and anticancer effects. Various methods have been reported to extract berberine from plants, mainly including classical and modern extraction methods. In these methods, organic solvents are often used which limits its uses because of the presence of solvent residue in extracted berberine from environmental and health point of view. Recently, the use of ionic liquids as green solvents in the extraction of organic compounds is becoming more common and is developing. Carbamates ionic liquids are a subset of ionic liquids that are liquid at ambient temperature and possess good polarity to extract and dissolve organic compounds. In this research, carbamate ionic liquid N, N-dipropyl ammonium N , N -dipropyl carbamate (DPCARB) was synthesized from the reaction of the second type of dipropylamine with dry ice (solid CO2) and charachterized by FTIR spectroscopy. Then the berberine in the stem and root of Berberis Vulgaris (South Khorasan province) was extracted. For this purpose, after grinding the plant samples and mesh sizing, the appropriate amounts were selected and extracted by Soxhlet apparatus as well as by multi-stages counter cuttent extraction method using DPCARB as solvent. The results were compared with the results of extraction of berberine by methanol solvent. The results showed that DPCARB ionic liquid is suitable for extraction of berberine but it has lower extraction efficiency than methanol. UV-Vis spectrophotometric method was used for analyzing the extracts and determining the concentration of berberine.‎
 
Iranian Research Organization for Science and Technology
Department of Chemical Technologies
Last updated on Oct - 28 2021
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